Tyck till om SwePub Sök
här!
Search: WFRF:(Leynaert Bénédicte)
> (2010-2014)
> (2011)
> Anto Josep
> Anto Josep M. >
Risk Factors for Ch...
Risk Factors for Chronic Obstructive Pulmonary Disease in a European Cohort of Young Adults
-
de Marco, Roberto (author)
-
Accordini, Simone (author)
-
Marcon, Alessandro (author)
-
show more...
-
Cerveri, Isa (author)
-
Anto, Josep M. (author)
-
Gislason, Thorarinn (author)
-
Heinrich, Joachim (author)
-
- Janson, Christer (author)
- Uppsala universitet,Lungmedicin och allergologi
-
Jarvis, Deborah (author)
-
Kuenzli, Nino (author)
-
Leynaert, Benedicte (author)
-
Sunyer, Jordi (author)
-
Svanes, Cecilie (author)
-
Wjst, Matthias (author)
-
Burney, Peter (author)
-
show less...
-
(creator_code:org_t)
- 2011
- 2011
- English.
-
In: American Journal of Respiratory and Critical Care Medicine. - 1073-449X .- 1535-4970. ; 183:7, s. 891-897
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Rationale: Few studies have investigated the factors associated with the early inception of chronic obstructive pulmonary disease (COPD). Objectives: We investigated COPD risk factors in an international cohort of young adults using different spirometric definitions of the disease. Methods. We studied 4,636 subjects without asthma who had prebronchodilator FEV1/FVC measured in the European Community Respiratory Health Survey both in 1991 to 1993 (when they were 20-44 yr old) and in 1999 to 2002. COPD was defined according to the Global Initiative for Chronic Obstructive Lung Disease fixed cut-off criterion (FEV1/FVC < 0.70), and two criteria based on the Quanjer and LuftiBus reference equations (FEV1/FVC less than lower limit of normal). COPD determinants were studied using two-level Poisson regression models. Measurements and Main Results: COPD incidence ranged from 1.85 (lower limit of normal [Quanjer]) to 2.88 (Global Initiative for Chronic Obstructive Lung Disease) cases/1,000/yr. Although about half of the cases had smoked less than 20 pack-years, smoking was the main risk factor for COPD, and it accounted for 29 to 39% of the new cases during the follow-up. Airway hyperresponsiveness was the second strongest risk factor (15-17% of new cases). Other determinants were respiratory infections in childhood and a family history of asthma, whereas the role of sex, age, and of being underweight largely depended on the definition of COPD used. Conclusions: COPD may start early in life. Smoking prevention should be given the highest priority to reduce COPD occurrence. Airway hyperresponsiveness, a family history of asthma, and respiratory infections in childhood are other important determinants of COPD. We suggest the need for a definition of COPD that is not exclusively based on spirometry.
Keyword
- bronchial hyperreactivity
- chronic obstructive pulmonary disease
- epidemiology
- reference values
- risk factors
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
de Marco, Robert ...
-
Accordini, Simon ...
-
Marcon, Alessand ...
-
Cerveri, Isa
-
Anto, Josep M.
-
Gislason, Thorar ...
-
show more...
-
Heinrich, Joachi ...
-
Janson, Christer
-
Jarvis, Deborah
-
Kuenzli, Nino
-
Leynaert, Benedi ...
-
Sunyer, Jordi
-
Svanes, Cecilie
-
Wjst, Matthias
-
Burney, Peter
-
show less...
- Articles in the publication
-
American Journal ...
- By the university
-
Uppsala University